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Smell, there is samples no discernable smell to Tretinoin Gel Microsphere,.04. The rest of the retinoids are only available through prescriptions, though some online pharmacies (Canadian, Indian, or otherwise) offer various generic versions without one. Generally, you go with the strongest retinoid you can tolerate with the least amount of irritation, even if that retinoid is considered weak. The extra conversion step it takes for retinyl palmitate to be converted tretinoin into usable retinoic acid means that you have to use a product with a very high concentration of retinyl palmitate to make it effective. I, myself, was under the impression for a long time that all Tretinoin Gel was the Mircosphere formula, but this is not the case. Tazarotene is the strongest retinoid, while retinol is the weakest (retinyl palmitate is even weaker than retinol - more on that below * ). Performance, packaging, tretinoin Gel Microsphere,.04 samples comes packaged in a basic metal tube. It was not a fun adjustment period, but after the first 8 weeks or so, I was rewarded with a brighter, clearer complexion, and significantly less acne than I had before I started the prescription. What kind of results did you get? Retinyl palmitate must first be converted to retinol, which is then converted to retinaldehyde, which is finally converted to retinoic acid, with some loss during each conversion step. Its nothing frilly, but its hygienic and gets the job done. If you have insurance, it may be significantly cheaper to get this through the pharmacy than it would through a questionable internet source. Different types of retinoids and their pros and cons. Therefore, retinol is weaker than retinaldehyde and retinaldehyde is weaker than retinoic acid. You are using any other medicines to treat your acne. It was later discovered that the very mechanism that allows Tretinoin eliminate acne also helps heal photodamage, reduce wrinkles, and slow the aging process. Ive done a little bit of experimentation as to what point in my routine this should be applied. Most dermatologists initially prescribe Differin for acne because it is the gentlest one out of all the prescription retinoids. You are allergic to any of the ingredients. For each conversion step, there is also some uncertainty as to how much of the retinoid was actually converted in the oxidation samples process (i.e. Tretinoin is a prescription-only treatment, as it is the actual all-trans retinoic acid, which is derived from Vitamin. It works as a cell-communicating agent, signaling cells in the deeper layers of the skin to create new, healthy skin cells and increasing cellular tretinoin turnover. . Tretinoin Gel Microsphere,.04 Ingredients: Tretinoin.04 in methyl methacrylate/glycol dimethacrylate Crosspolymer (Microsponge System benzyl alcohol, butylated hydroxytoluene, carbomer 974P, cyclomethicone and dimethicone copolyol, disodium edta, glycerin, PPG-20 methyl glucose ether distearate, propylene glycol, purified water, sorbic acid, trolamine. The effectiveness of Tretinoin more than made up for the increased sensitivity I experienced, and after the first 9 months, my skin seemed to adjust it was still sensitive, but far less. It has been just as effective at keeping my acne at bay as my Tretinoin Cream was, but I find the Gel Microsphere to be far less irritating. I imagine this is largely due to the fact that Id been using the Tretinoin Cream for so long before stopping, but I was surprised that I didnt experience ill effects from stopping for so long in between. At the very least, you are better off using a retinol product (check the ingredient list for it on the product label). For a complete list of drug precautions, you can view the patient information here. When you apply a retinoid product that is retinoic acid (ex. I also had a few mishaps that involved applying too much Tretinoin cream. Additionally, Wal-mart, Target, Harris Teeter, and Rite-Aid all have 4 prescription drug plans for generic medications (which includes Tretinoin Gel Microsphere) in many US states.