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Ankylosing Spondylitis: Symptoms, Diagnosis, and Treatment. Last updated on Dec 17, 2018. Renal Toxicity And Hyperkalemia Renal Toxicity Long-term administration of nsaids has resulted in renal papillary necrosis and other renal injury. This information is not a substitute for medical advice. In the general.S. Since celecoxib is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues. Cardiovascular Outcomes Trial: Prospective Randomized Evaluation of Celecoxib Integrated Safety. For this category: Studies show a risk of adverse effects generic to the fetus when the mother takes the drug. Multimedia: Slideshows, Images Quizzes, rheumatoid Arthritis (RA) Symptoms Treatment. Hypertension nsaids, including celebrex, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of CV events. 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